News
Jun 29, 2015

Studien til sentermedlem Marit Kristine Smedsrud, MD, PhD er omtalt på hjertebloggen til UNIKARD


 

Marit Kristine Smedsrud, MD, PhD har sammen med sine kollegaer oppdaget at forhøyede nivåer av troponin I og N-terminal pro-B-type natriuretisk peptid (NT-proBNP) har sammenheng med svekket sammentrekningskraft i venstre ventrikkel hos pasienter med stabil koronarsykdom.

Studien "Sensitive cardiac troponins and N-terminal pro-B-type natriuretic peptide in stable coronary artery disease: correlation with left ventricular function as assessed by myocardial strain." ble publisert i The International Journal of Cardiovascular Imaging i juni 2015.

Marit Kristine Smedsrud, MD, PhD er førsteforfatter. Medforfattere fra CCI inkluderer Christian Eek, MD, PhD, Helge Skulstad, MD, PhD, Lars Aaberge, MD, PhD og senterleder Thor Edvardsen, MD, PhD.

Studien er omtalt på hjertebloggen til UNIKARD

Posted by: Anonymous

ABSTRACT

N-terminal pro-B-type natriuretic peptide (NT-proBNP) and cardiac troponins (cTns) measured with sensitive assays provide strong prognostic information in patients with stable coronary artery disease. However, the relationship between these biomarkers and myocardial contractile function, as well as infarct size, in this patient group, remains to be defined.

The study population consisted of 160 patients referred to a follow-up echocardiography scheduled 1 year after coronary revascularization. Concentrations of NT-proBNP, high-sensitive cTnT (hs-cTnT) and sensitive cTnI assays were assessed. Left ventricular function was measured as global peak systolic longitudinal strain by speckle tracking echocardiography and infarct size was assessed by late-enhancement MRI. NT-proBNP and sensitive cTnI levels were significantly associated with left ventricular function by peak systolic strain (R-values 0.243 and 0.228, p = 0.002 and 0.004) as well as infarct size (R-values 0.343 and 0.366, p = 0.014 and p = 0.008). In contrast, hs-cTnT did not correlate with left ventricular function (R = 0.095, p = 0.231) and only marginally with infarct size (R = 0.237, p = 0.094).

NT-proBNP and sensitive cTnI levels correlate with left ventricular function and infarct size in patients with stable coronary artery disease after revascularization. As opposed to hs-cTnT, NT-proBNP and cTnI seem to be indicators of incipient myocardial dysfunction and the extent of myocardial necrosis.

 

Sensitive cardiac troponins and N-terminal pro-B-type natriuretic peptide in stable coronary artery disease: correlation with left ventricular function as assessed by myocardial strain.
Smedsrud MK, Gravning J, Omland T, Eek C, Mørkrid L, Skulstad HAaberge L, Bendz B, Kjekshus J, Edvardsen T
Int J Cardiovasc Imaging. 2015 Jun;31(5):967-73
Epub 2015 Mar 19.
doi: 10.1007/s10554-015-0646-6
PMID: 25788439

Center for Cardiological Innovation